Тable 3. Dynamics of cytokines in saliva depending on the size of the tumor

Indicator

T1N0-3M0-1, n=9

T2N0-3M0-1, n=30

T3N0-3M0-1, n=21

T4N0-3M0-1, n=10

IL-2

2.61 [1.66; 4.94]

1.11 [0.64; 2.13]

p=0.0069

1.14 [0.81; 2.73]

p=0.0404

1.02 [0.60; 2.52]

p=0.0410

IL-4

1.47 [0.68; 2.00]

1.00 [0.16; 1.66]

0.53 [0.20; 1.05]

p=0.0193

0.73 [0.35; 1.16]

IL-6

0.86 [0.56; 3.93]

0.75 [0.44; 2.34]

1.18 [0.33; 1.81]

4.17 [4.00; 4.33]

IL-8

68.90 [54.40; 171.50]

130.00 [66.58; 249.00]

98.20 [51.70; 160.16]

151.00 [117.00; 331.72]

IL-10

2.71 [1.93; 13.10]

2.01 [0.91; 2.65]

p=0.0486

2.09 [1.29; 3.03]

1.78 [1.33; 2.41]

p=0.0485

IL-18

19.10 [9.68; 60.55]

9.80 [4.28; 68.90]

11.50 [4.59; 33.80]

42.40 [13.60; 170.00]

CRP

0.017 [0.015; 0.020]

0.024 [0.015; 0.041]

0.033 [0.012; 0.121]

0.044 [0.024; 0.056]

p=0.0367

TNF-α

No data

No data

0.88 [0.49; 1.71]

1.26 [0.42; 1.90]

Notes. p – statistically significant differences compared to the group T1N0-3M0-1