Тable 4. Dynamics of cytokine level in saliva depending on the presence/absence of regional and distant metastasis

Parameter

N0M0, n=31

N1-3M0, n=22

N1-3M1, n=14

IL-2

1.18 [0.64; 2.21]

1.16 [0.70; 2.35]

1.01 [0.60; 2.73]

IL-4

0.88 [0.16; 1.59]

0.69 [0.29; 1.16]

0.69 [0.25; 1.75]

IL-6

0.56 [0.33; 3.93]

1.39 [0.91; 4.00]

1.67 [0.47; 2.34]

IL-8

96.40 [60.30; 242.00]

125.03 [79.40; 214.00]

100.00 [46.30; 231.00]

IL-10

2.09 [0.85; 3.03]

1.79 [1.29; 2.87]

1.93 [1.31; 3.10]

IL-18

8.93 [4.04; 21.70]

13.60 [8.76; 61.80]

p=0.0461

33.80 [17.50; 111.00]

p=0.0236

CRP

0.016 [0.015; 0.028]

0.057 [0.021; 0165]

p=0.0076

0.034 [0.027; 0053]

p=0.0486

TNF-α

0.49

1.38 [0.76; 1.90]

0.95 [0.19; 1.71]

Notes. p – statistically significant differences compared to the group N0M0