Table 2. The ability of conjugates 4a,b and 5 а,b to displace propidium from the peripheral anionic site of EeAChE and scavenge free radicals in the ABTS test.
|
Compound |
Propidium displacement, %
|
ABTS scavenging activity,
|
|
4a |
23.3 ± 2.1 |
1.32 ± 0.03 |
|
4b |
21.2 ± 2.3 |
1.45 ± 0.06 |
|
5a |
31.5 ± 2.7 |
0.47 ± 0.05 |
|
5b |
29.4 ± 2.8 |
0.48 ± 0.04 |
|
Tacrine |
4.4 ± 0.6 |
0 |
|
Donepezil |
10.1 ± 0.6 |
-** |
|
Trolox |
- |
1.0 |
|
Ascorbic acid |
- |
0.98 ± 0.04 |
Note: *TEAC (trolox equivalent antioxidant capacity) – was determined from the ratio of the slopes of the concentration−response curves, test compound/Trolox; ** - not determined