Figure 1. Hypothetical scheme of Casp-2 AS as a result of SSO action. Hypothetical scheme of Casp-2 mRNA AS (A). Inclusion of exon 9 in mRNA transcript leads to the formation of preliminary stop-codon and to the synthesis of truncated Casp-2S splice-variant. Schematic presentation of splicing-regulating protein SF2/ASF (shown as white ellipse) and SRp30c (shown as grey ellipse), which bound to splicing cites (shown in the black frames) on Casp-2 pre-mRNA (В). Base-pairing of SSO to Casp-2 pre-mRNA blocks the binding of both SF2/ASF and SRp30c to their functional sites (C). Such interaction results in induction of AS and inclusion of exon 9.