Table 3. Approved ADC Drugs Based on Bispecific Antibodies on the Global Market

Trade Name

Target

Manufacturer

Indications

Blincyto (blinatumomab)

CD19 / CD3 (BiTE)

Amgen

B-cell acute lymphoblastic leukemia [59]

Imdelltra (tarlatamab-dlle)

DLL3 / CD3

Amgen

Relapsed/refractory small cell lung cancer [60]

Rybrevant (amivantamab-vmjw)

EGFR / c-Met

Johnson & Johnson

Non-small cell lung cancer [61]

Tecvayli (teclistamab-cqyv)

BCMA / CD3

Johnson & Johnson

Multiple myeloma [62]

Lunsumio (mosunetuzumab-axgb)

CD20 / CD3 (2:1 format)

Roche / Genentech

Follicular lymphoma [63]

Columvi (glofitamab-gxbm)

CD20 / CD3

Roche / Genentech

Diffuse large B-cell lymphoma [64]

Talvey (talquetamab-tgvs)

GPRC5D / CD3

Johnson & Johnson

Multiple myeloma [65]

Epkinly (epcoritamab-bysp)

CD20 / CD3

AbbVie / Genmab

Diffuse large B-cell lymphoma [66]

Elrexfio (elranatamab)

BCMA / CD3

Pfizer

Multiple myeloma [67]

Imdelltra (tarlatamab)

BCMA / CD3

Johnson & Johnson

Multiple myeloma [68]