Table 3. Approved ADC Drugs Based on Bispecific Antibodies on the Global Market
|
Trade Name |
Target |
Manufacturer |
Indications |
|
Blincyto (blinatumomab) |
CD19 / CD3 (BiTE) |
Amgen |
B-cell acute lymphoblastic leukemia [59] |
|
Imdelltra (tarlatamab-dlle) |
DLL3 / CD3 |
Amgen |
Relapsed/refractory small cell lung cancer [60] |
|
Rybrevant (amivantamab-vmjw) |
EGFR / c-Met |
Johnson & Johnson |
Non-small cell lung cancer [61] |
|
Tecvayli (teclistamab-cqyv) |
BCMA / CD3 |
Johnson & Johnson |
Multiple myeloma [62] |
|
Lunsumio (mosunetuzumab-axgb) |
CD20 / CD3 (2:1 format) |
Roche / Genentech |
Follicular lymphoma [63] |
|
Columvi (glofitamab-gxbm) |
CD20 / CD3 |
Roche / Genentech |
Diffuse large B-cell lymphoma [64] |
|
Talvey (talquetamab-tgvs) |
GPRC5D / CD3 |
Johnson & Johnson |
Multiple myeloma [65] |
|
Epkinly (epcoritamab-bysp) |
CD20 / CD3 |
AbbVie / Genmab |
Diffuse large B-cell lymphoma [66] |
|
Elrexfio (elranatamab) |
BCMA / CD3 |
Pfizer |
Multiple myeloma [67] |
|
Imdelltra (tarlatamab) |
BCMA / CD3 |
Johnson & Johnson |
Multiple myeloma [68] |