Transporters

Functions

SLC17A5

It participates in nitrate (NO₃⁻) uptake. This is important for the nitrate-nitrite-nitric oxide pathway, which facilitates nitric oxide signaling in mammals.

SLC4A2

It is an electroneutral transporter. It participates in the exchange of chlorides (Cl⁻) and bicarbonates (HCO₃⁻), thereby regulating intracellular pH and chloride concentration in salivary gland cells.

SLC2A4 and SLC26A6

It is involved in the secretion of iodide (I⁻) and bicarbonate (HCO₃⁻), and also regulates the transmembrane conductance regulator in cystic fibrosis in the parotid duct.

SLC5A5

Belongs to the sodium/iodide symporter. Expressed at higher levels than SLC17A5.

SLC15A2

Absorption of peptides and some drugs.

SLCO1A2

Transfer of organic anions and regulation of the influx and outflow of their substrates, regulation of salivary secretion.

SLC22A1

Transport of organic cations, absorption and excretion of drugs and toxins.

SLC22A3

Absorbs and secretes organic cations from the blood into the acinar cells of the salivary glands. It is responsible for the accumulation of drugs, such as metformin, in the salivary glands, which can lead to drug-induced taste disturbances.

SLC22A4

Transporter of carnitine and other organic cations.

SLC22A5

A transporter of carnitine into cells. It is crucial for fatty acid metabolism and energy production in the mitochondria.

SLC22A6

A transporter of organic anions, involved in the regulation of the secretion of endogenous and exogenous molecules, including drugs and other metabolites, into saliva.

SLC22A7

Organic anion transporter. Other functions of the transporter are little studied.