Changes in the Metabolism of Fucose-Containing Biopolymers in Rat Gastrointestinal Tissues under Immobilization Stress

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A.V. Oksuzyan
E.G. Butolin
A.A. Bryzgalina


The features of fucoglycoprotein metabolism in blood serum and tissues of gastrointestinal tract of rats in the dynamics of experimental stress on 21, 35, 60, 90 days of observation were considered. In blood serum and in homogenates of liver, stomach and small intestine of immobilized rats multidirectional changes in the level of fucose and fucosidase activity were observed. They are manifested by a decrease in the amount of total fucose in blood serum and liver of rats against the background of low activity of the enzyme degrading fucoglycoproteins. The same changes were detected in the tissues of the gastric and small intestine (except on day 35 of the experiment, when the growth of fucose and fucosidase was visualized), which may indicate a change in metabolism toward anabolism. These changes correlate with an increase in the concentration of corticosterone in the blood serum of the rats.

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Oksuzyan, A., Butolin, E., & Bryzgalina, A. (2024). Changes in the Metabolism of Fucose-Containing Biopolymers in Rat Gastrointestinal Tissues under Immobilization Stress. Biomedical Chemistry: Research and Methods, 7(1), e00214.


  1. Khnychenko L. K., Sapronov N. S. (2003) Stress and its role in the development of pathological processes. Reviews of Clinical Pharmacology and Drug Therapy, 2(3), 2-15.
  2. Semenov V., Volkov A. (2016) The influence of stress factors of various forces on the neurohumoral and immune systems of the animal body. Farm Animal Veterinary Science, 12, 35-39.
  3. Oksuzyan A.V., Butolin E.G., Ivanov G.V. (2022) Changes in the content of fucoglycoproteins in the mucous membranes and walls of the stomach and small intestine of alcoholized rats under immobilization stress. Medical academic journal, 22(3), 37-48. DOI
  4. Volkhina I. V., Naumova N. G. (2012) Тhе comparative analysis of changes of the exchange indices for biopolymers of the connective tissue in the stomach wall at immobilisation at rats with different reaction to stress. Bulletin of the Udmurt University. The series "Biology. Earth Sciences", 1, 55-58.
  5. Oksuzyan, A.V., Nurmieva D. I., Subbotina E. S. (2022) Changes in the parameters of sialoglycoproteins in the tissues of the small intestine of alcoholized rats under conditions of immobilization. Modern Science, 4(1), 19-22.
  6. Cherenkov D. A., Rybakov Yu. A., Sanina T. V., Shkarin N. Yu., Skladnev D. A., Korneeva O. S. (2010) Fucose: biological role, obtaining and application. Biotechnology in Russia , 6, 63-71.
  7. Kononova S. V. (2017) How fucose of blood group glycotopes programs the human intestinal microbiota. Biochemistry, 82(9), 1259-1277. DOI
  8. Sharaev P. N., Kildiyarova R. R., Strelkov N. S., Butolin E.G., Ozhegov A.M. (2009) Connective tissue in childhood. State Budgetary Educational Institution of Higher Professional Education "Izhevsk State Medical Academy" of the Ministry of Health of the Russian Federation, 144 p. ISBN: 978-5-91385-018-8
  9. Protasova S. V., Butolin E. G., Oksuzyan A.V. (2010) Metabolism of carbohydrate-containing biopolymers in the liver and gastric mucosa in experimental diabetes in rats with different resistance to stress. Diabetes Mellitus, 1, 10-12.
  10. Oksuzyan, A., Maier, H., McGue, M., Vaupel, J. W., Christensen, K. (2010). Sex differences in the level and rate of change of physical function and grip strength in the Danish 1905-cohort study. Journal of Aging and Health, 22(5), 589-610. DOI
  11. Jacobsen, R., Oksuzyan, A., Engberg, H., Jeune, B., Vaupel, J. W., Christensen, K. (2008). Sex differential in mortality trends of old-aged Danes: a nationwide study of age, period and cohort effects. European journal of epidemiology, 23, 723-730. DOI