Drug Analysis Methods

Authors

  • V.V. Shumyantseva Institute of Biomedical Chemistry, 10 Pogodinskaya str., Moscow, 119121 Russia; Pirogov Russian National Research Medical University, 1 Ostrovitianov str., Moscow 117997, Russia
  • T.V. Bulko Institute of Biomedical Chemistry, 10 Pogodinskaya str., Moscow, 119121 Russia
  • P.I. Koroleva Institute of Biomedical Chemistry, 10 Pogodinskaya str., Moscow, 119121 Russia

DOI:

https://doi.org/10.18097/BMCRM00110

Keywords:

erythromycin; acetaminophen; ibuprofen; μ diclofenac; medications; electroanalysis

Abstract

Modern methods of analysis of drugs for their quantitative assessment are considered. Particular attention is paid to the electrochemical methods of drug registration, based on the reaction of electrooxidation of molecules. Systems and materials for modifying electrodes are described, as well as methods for producing modified electrodes for electrochemical reactions on the surface of electrodes. The authors present data on the electroanalysis of acetaminophen, diclofenac, ibuprofen, omeprazole, using electrodes modified with carbon nanomaterials based on carbon nanotubes and graphene. It was shown that electroanalytical methods allow the registration of therapeutic drugs in a wide range of detectable concentrations (0.1 μМ - 10 mM), which can be used to work with biological fluids (plasma, blood, urine), to conduct drug monitoring and study drug-drug interactions.

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Published

2019-12-23

How to Cite

Shumyantseva, V., Bulko, T., & Koroleva, P. (2019). Drug Analysis Methods. Biomedical Chemistry: Research and Methods, 2(4), e00110. https://doi.org/10.18097/BMCRM00110

Issue

Section

PROTOCOLS OF EXPERIMENTS, USEFUL MODELS, PROGRAMS AND SERVICES