Algorithms for Calculation of Parameters of Electrochemical Biosensor

Authors

  • V.V. Shumyantseva Institute of Biomedical Chemistry, 10 Pogodinskaya str., Moscow, 119121 Russia; Pirogov Russian National Research Medical University, Moscow, Russia
  • V.V. Pronina Institute of Biomedical Chemistry, 10 Pogodinskaya str., Moscow, 119121 Russia

DOI:

https://doi.org/10.18097/BMCRM00178

Keywords:

pharmacogenomics; DNA analysis; binding constant; electroactive electrode surface; electrochemical biosensor

Abstract

The aim of this work is to present the experimental results in the form of an algorithm for analyzing the modification of screen printed electrodes, including the possibility of its regeneration for irreversibly oxidizing biologically active compounds (drugs, DNA and proteins). A protocol was developed for quantitative analysis and study of the mechanism of drug-DNA interaction by differential pulse voltammetry, including the following parameters: complex binding constant, Gibbs free energy, and electrochemical coefficients of the toxic effect.

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Published

2022-09-22

How to Cite

Shumyantseva, V., & Pronina, V. (2022). Algorithms for Calculation of Parameters of Electrochemical Biosensor. Biomedical Chemistry: Research and Methods, 5(3), e00178. https://doi.org/10.18097/BMCRM00178

Issue

Section

PROTOCOLS OF EXPERIMENTS, USEFUL MODELS, PROGRAMS AND SERVICES