Гематосаливарный барьер как многогранная система: литературный обзор

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Опубликован: May 28, 2026
DOI: https://doi.org/10.18097/BMCRM00307
Ключевые слова:
гематосаливарный барьер; слюнные железы; слизистая оболочка полости рта; микробиом; иммунная система; межклеточные связи

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Е.И. Дьяченко
Научно-исследовательская лаборатория биохимии, Омский государственный педагогический университет, 644099, Омск, ул. Набережная Тухачевского, 14
Е.А. Сарф
Научно-исследовательская лаборатория биохимии, Омский государственный педагогический университет, 644099, Омск, ул. Набережная Тухачевского, 14
Л.В. Бельская
Научно-исследовательская лаборатория биохимии, Омский государственный педагогический университет, 644099, Омск, ул. Набережная Тухачевского, 14

Аннотация

Цель данного обзора — дать всестороннее описание гематосаливарного барьера, систематизировать результаты последних исследований его структуры и функции в норме и при патологии. Гематосаливарный (ГСБ) барьер – многогранная система, ключевыми компонентами которой являются слюнные железы, эпителий полости рта, белки межклеточных соединений, поддерживающие прочность барьера, а также слюна и слизь. Кровоснабжение барьера, нервные связи, местные иммунные реакции и микробиом полости рта создают среду, в которой функционирует ГСБ. При оценке ГСБ необходимо учитывать ряд дополнительных факторов, включая иннервацию, кровоснабжение, наличие циркулирующих метаболитов в сосудах, снабжающих эпителий полости рта и слюнные железы, а также объем выделяемой слюны и ее реологические свойства, состав микробиома полости рта и состояние иммунной системы.

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Как цитировать
Дьяченко E., Сарф E., & Бельская L. (2026). Гематосаливарный барьер как многогранная система: литературный обзор. Biomedical Chemistry: Research and Methods, 9(2), e00307. https://doi.org/10.18097/BMCRM00307
Выпуск
Том 9 № 2 (2026): Принято в печать
Раздел
ОБЗОРЫ

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