Some Methods for Managing the Degradation of Biomedical Implantable Materials Based on Collagen and Hyaluronic Acid

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Published: Nov 25, 2025
DOI: https://doi.org/10.18097/BMCRM00289
Keywords:
hyaluronic acid; degradation; collagen; polymer matrix

Main Article Content

I.S. Rudik
Central Research Institute of Dentistry and Maxillofacial Surgery, 16 Timur Frunze str., Moscow, 119021
A.V. Vasiliev
Central Research Institute of Dentistry and Maxillofacial Surgery, 16 Timur Frunze str., Moscow, 119021; Sechenov First Moscow State Medical University, 8 Trubetskaya str., Moscow, 119048 Russia
A.V. Mironov
National Research Centre “Kurchatov Institute”, 1 Academician Kurchatov sq., Moscow, 123182 Russia
V.S. Kuznetsova
Central Research Institute of Dentistry and Maxillofacial Surgery, 16 Timur Frunze str., Moscow, 119021
F.F. Losev
Central Research Institute of Dentistry and Maxillofacial Surgery, 16 Timur Frunze str., Moscow, 119021; Sechenov First Moscow State Medical University, 8 Trubetskaya str., Moscow, 119048 Russia

Abstract

The review considers modern approaches to modifying the in vitro degradation kinetics of implantable matrices based on collagen and hyaluronic acid. It includes data presented in 24 of approximately one hundred articles on similar topics found. Special attention is paid to the effect of polymer additives in collagen- and hyaluronic acid-based materials on their degradation rates in hydrolytic and enzymatic environments. The mechanisms of interaction of components and the impact of their structure on degradation processes are described. Approaches to the development of implantable medical devices based on biopolymers with controlled degradation and biocompatibility properties are proposed.

Article Details

How to Cite
Rudik, I., Vasiliev, A., Mironov, A., Kuznetsova, V., & Losev, F. (2025). Some Methods for Managing the Degradation of Biomedical Implantable Materials Based on Collagen and Hyaluronic Acid. Biomedical Chemistry: Research and Methods, 8(4), e00289. https://doi.org/10.18097/BMCRM00289
Issue
Vol. 8 No. 4 (2025): Online first
Section
REVIEWS

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